Response to nematode

pathway activity — cross-omics
GO:0009624Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Response to nematode pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGS2, FUNDC2P1, and ELOBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCPTGS2 →+1.693+0.464<.001<.00134
CCRCCFUNDC2P1 →+0.536+0.800.001.00933
LSCCELOBP2 →-0.845-0.513.002.00333
GBMSDAD1P2 →-0.082-0.094.006.00733
OVCASC4P1 →-0.770-0.875.002<.00133
OVMCEMP1 →+0.410+0.667.009.00833
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration