Response to mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Response to mechanical stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL6A3, SRRM2_S1444, and CLPX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mechanical stimulus activity versus COL6A3 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL6A3 →	+0.778	+0.033	<.001	<.001	3	9
LUAD	SRRM2_S1444 →	-0.607	-0.027	<.001	.001	3	9
LSCC	CLPX →	-0.396	-0.039	<.001	<.001	3	9
GBM	F13A1 →	+0.854	+0.052	<.001	<.001	3	9
OV	ILK →	+0.488	+0.037	<.001	<.001	3	9
BRCA	LMCD1 →	+0.564	+0.025	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009612 vs COL6A3 — GBM

Explore this scatter interactively →