Response to mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Response to mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAS2R19, TMED8, and SLC25A35, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mechanical stimulus activity versus TAS2R19 in COAD (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TAS2R19 →	-0.515	-1.146	.001	.004	3	2
BRCA	TMED8 →	-1.245	-0.449	<.001	.003	2	2
BRCA	SLC25A35 →	-2.110	-0.449	.001	.003	2	2
BRCA	YTHDC2 →	-1.499	-0.449	.006	.003	2	2
BRCA	NCBP3 →	-0.745	-0.449	.003	.003	2	2
BRCA	MAP3K1 →	-2.101	-0.449	<.001	.003	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009612 vs TAS2R19 — COAD

Explore this scatter interactively →