Response to mechanical stimulus

Across TCGA cell cohorts, RNA activity of the Response to mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGKA, GIPC1, and TACSTD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mechanical stimulus activity versus DGKA in OESOPHAGUS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DGKA →	+1.723	+0.280	.004	<.001	3	7
LUNG_NSCLC_LUAD	GIPC1 →	+0.889	+0.201	<.001	.001	3	7
PANCREAS	TACSTD2 →	+6.611	+0.384	<.001	.004	3	7
STOMACH	SLC2A1 →	+3.226	+0.374	<.001	<.001	3	7
PANCREAS	VGLL1 →	+3.663	+0.332	<.001	<.001	3	6
PANCREAS	PPP1R13L →	+1.354	+0.276	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009612 vs DGKA — OESOPHAGUS

Explore this scatter interactively →