Response to symbiont

Across TCGA patient cohorts, RNA activity of the Response to symbiont pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP10, LCP2, and SASH3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to symbiont activity versus CASP10 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CASP10 →	+0.443	+0.140	<.001	<.001	3	9
GBM	LCP2 →	+0.471	+0.087	<.001	<.001	3	7
GBM	SASH3 →	+0.493	+0.122	<.001	<.001	3	7
LSCC	ATG7 →	+0.222	+0.101	<.001	<.001	3	7
LSCC	EVI2B_S268 →	+1.066	+0.144	<.001	<.001	3	7
GBM	LGALS9 →	+0.523	+0.115	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009608 vs CASP10 — LSCC

Explore this scatter interactively →