Response to symbiont

Across TCGA patient cohorts, RNA activity of the Response to symbiont pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, SOCS3, and SLC2A3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to symbiont activity versus MMP19 in BRCA (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MMP19 →	+1.108	+0.197	<.001	<.001	3	8
OV	SOCS3 →	+0.965	+0.133	.004	.008	3	8
PDAC	SLC2A3 →	+0.955	+0.135	<.001	.001	3	7
GBM	LILRA6 →	+0.666	+0.106	<.001	.001	3	7
GBM	CEACAM3 →	+0.525	+0.151	.006	.001	3	6
BRCA	SLC11A1 →	+1.109	+0.175	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009608 vs MMP19 — BRCA

Explore this scatter interactively →