Response to symbiont

Across TCGA cell cohorts, RNA activity of the Response to symbiont pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL4A, FOXC2, and CCDC187, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL4A grouped by Response to symbiont-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ARL4A →	-0.230	-1.612	.003	<.001	3	4
LUNG_NSCLC_LUAD	FOXC2 →	-0.230	-1.162	<.001	<.001	3	4
BLOOD_Myeloma	CCDC187 →	+0.236	+1.823	.003	<.001	3	3
LUNG_NSCLC_LUAD	RAC1 →	+0.302	+1.137	.001	<.001	3	3
OVARY	RCOR2 →	+0.418	+1.415	<.001	.005	3	3
BREAST	MLLT1 →	+0.220	+0.921	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL4A by Response to symbiont activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →