Detection of virus

Across TCGA patient cohorts, RNA activity of the Detection of virus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, PSMB6, and TLR3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of virus activity versus TRIM21 in LSCC (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM21 →	+0.381	+0.055	<.001	<.001	3	8
OV	PSMB6 →	-0.383	-0.047	.002	.005	3	8
LUAD	TLR3 →	+0.641	+0.076	<.001	<.001	3	7
HNSC	TRIM22 →	+0.498	+0.063	<.001	<.001	3	7
OV	NMI →	+0.407	+0.051	<.001	<.001	3	7
GBM	PSMB10 →	+0.581	+0.094	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009597 vs TRIM21 — LSCC

Explore this scatter interactively →