Detection of virus

Across TCGA patient cohorts, RNA activity of the Detection of virus pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMPK2, DDX60L, and CDKN1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of virus activity versus CMPK2 in PDAC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CMPK2 →	+1.054	+0.470	<.001	<.001	3	4
UCEC	DDX60L →	+0.594	+0.772	.002	<.001	2	5
OV	CDKN1C →	-0.991	-0.575	.002	.006	3	4
COAD	NDUFV2P1 →	+0.402	+0.575	.002	.001	3	4
PDAC	OAS2 →	+1.180	+0.405	<.001	.008	3	4
LSCC	IFIH1 →	+0.844	+0.915	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009597 vs CMPK2 — PDAC

Explore this scatter interactively →