Detection of virus

Across TCGA cell cohorts, RNA activity of the Detection of virus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GALNAC1, ITGAV, and SMDT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST6GALNAC1 grouped by Detection of virus-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ST6GALNAC1 →	-3.384	-1.281	.001	.001	3	6
KIDNEY	ITGAV →	+1.409	+1.304	<.001	.002	3	5
BLOOD_Lymphoma	SMDT1 →	-1.769	-2.209	.005	.003	3	5
PANCREAS	TMEM167A →	+0.824	+1.839	<.001	.001	3	5
BREAST	TFF3 →	-3.978	-1.011	<.001	<.001	3	5
LUNG_SCLC	CAMSAP3 →	-1.633	-1.174	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST6GALNAC1 by Detection of virus activity — STOMACH

Explore this box plot interactively →