Detection of light stimulus

Across TCGA cell cohorts, RNA activity of the Detection of light stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA2, REEP6, and SNX30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of light stimulus activity versus GOLGA2 in SKIN (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GOLGA2 →	+0.533	+1.172	.004	.002	3	5
PANCREAS	REEP6 →	+1.638	+1.320	<.001	.001	3	5
CNS	SNX30 →	+0.638	+1.212	.007	<.001	3	4
CNS	RAD23B →	+0.375	+1.214	.008	<.001	2	5
LUNG_NSCLC_LUSC	CPSF2 →	-0.694	-1.495	.005	.001	3	4
OVARY	MRPL30 →	-0.464	-1.314	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009583 vs GOLGA2 — SKIN

Explore this scatter interactively →