Detection of light stimulus

Across TCGA cell cohorts, RNA activity of the Detection of light stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNA11, GNAQ, and TRMT112, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of light stimulus activity versus GNA11 in LIVER (Pearson r = 0.76).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GNA11 →	+1.738	+2.044	.003	<.001	2	13
OESOPHAGUS	GNAQ →	+1.031	+1.312	<.001	<.001	3	10
OVARY	TRMT112 →	-1.004	-1.111	.007	.004	3	9
BREAST	REEP6 →	+2.065	+1.258	<.001	<.001	3	9
LARGE_INTESTINE	HSPA8 →	-0.785	-1.115	.002	.002	3	8
OVARY	CBL →	-1.313	-1.156	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009583 vs GNA11 — LIVER

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