Detection of abiotic stimulus

Across TCGA patient cohorts, RNA activity of the Detection of abiotic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, SYT7, and SUGP1_S485, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of abiotic stimulus activity versus FERMT2 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FERMT2 →	-0.406	-0.013	<.001	<.001	3	5
GBM	SYT7 →	+0.651	+0.022	.002	<.001	3	5
PDAC	SUGP1_S485 →	-0.399	-0.017	.008	.002	3	4
GBM	ICA1 →	+0.368	+0.028	<.001	<.001	3	4
OV	ARL3 →	+0.293	+0.017	.001	.003	3	4
LUAD	RPS6KA3 →	-0.282	-0.023	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009582 vs FERMT2 — BRCA

Explore this scatter interactively →