Detection of abiotic stimulus

Across TCGA patient cohorts, RNA activity of the Detection of abiotic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CERS2, LARP1B_S900, and SLC52A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of abiotic stimulus activity versus CERS2 in UCEC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CERS2 →	+0.427	+0.156	<.001	.006	3	3
UCEC	LARP1B_S900 →	-0.650	-0.233	<.001	<.001	3	3
BRCA	SLC52A2 →	+1.289	+0.173	<.001	<.001	3	3
UCEC	ATP5MG →	+0.538	+0.307	.004	.003	3	3
UCEC	DNAJB14 →	+0.478	+0.278	<.001	<.001	3	3
UCEC	TMEM100_S121 →	+1.275	+0.223	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009582 vs CERS2 — UCEC

Explore this scatter interactively →