Detection of abiotic stimulus

Across TCGA cell cohorts, RNA activity of the Detection of abiotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP20, NFKB1, and FH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP20 grouped by Detection of abiotic stimulus-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CFAP20 →	+0.689	+0.289	<.001	<.001	3	4
BLOOD_Lymphoma	NFKB1 →	+0.953	+0.197	.009	.005	3	4
LARGE_INTESTINE	FH →	+0.585	+0.168	<.001	<.001	3	4
BLOOD_Myeloma	GMCL1 →	+0.411	+1.596	.004	.002	3	3
STOMACH	AKT2 →	+1.095	+0.260	.004	.007	3	3
STOMACH	AMFR →	+0.987	+0.255	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP20 by Detection of abiotic stimulus activity — STOMACH

Explore this box plot interactively →