Detection of abiotic stimulus

Across TCGA cell cohorts, RNA activity of the Detection of abiotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAK16, IL36RN, and PKP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of abiotic stimulus activity versus MAK16 in BONE (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAK16 →	-1.127	-1.660	.009	.001	3	6
LUNG_NSCLC_LUAD	IL36RN →	+0.947	+0.672	<.001	.008	3	5
LUNG_NSCLC_LUAD	PKP3 →	+1.464	+0.608	<.001	.001	3	5
LUNG_SCLC	LAD1 →	+2.452	+1.224	<.001	<.001	3	4
LUNG_SCLC	C6orf132 →	+1.843	+0.994	<.001	<.001	3	4
LUNG_SCLC	MYO6 →	+1.564	+0.763	.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009582 vs MAK16 — BONE

Explore this scatter interactively →