Fertilization

Across TCGA patient cohorts, RNA activity of the Fertilization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPG, JCAD, and TRAF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fertilization activity versus CAPG in BRCA (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAPG →	-0.638	-0.155	<.001	.001	3	6
CCRCC	JCAD →	+0.648	+0.142	<.001	.003	3	4
LUAD	TRAF1 →	-0.621	-0.073	<.001	.008	3	4
COAD	TRAV38-1 →	-0.442	-0.117	.006	.007	3	4
COAD	KRT18P39 →	-0.317	-0.159	.002	.003	3	4
COAD	WDR45P1 →	-0.242	-0.157	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009566 vs CAPG — BRCA

Explore this scatter interactively →