Fertilization

Across TCGA cell cohorts, RNA activity of the Fertilization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC3A2, FYN, and ODF2L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC3A2 grouped by Fertilization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC3A2 →	-1.130	-0.266	.001	<.001	3	3
LIVER	FYN →	+2.138	+0.534	.007	.001	3	3
LIVER	ODF2L →	-2.366	-0.440	<.001	.001	3	3
LIVER	CIB2 →	-1.282	-0.398	.003	.005	3	3
LIVER	B3GNT4 →	-0.731	-0.420	.005	.001	3	3
LIVER	MYO1D →	-2.528	-0.450	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC3A2 by Fertilization activity — OESOPHAGUS

Explore this box plot interactively →