RNA modification

Across TCGA patient cohorts, RNA activity of the RNA modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SND1_S645, GTF3C2_S167, and PHF20L1_S433, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA modification activity versus SND1_S645 in LSCC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SND1_S645 →	-0.749	-0.025	<.001	.002	3	5
LSCC	GTF3C2_S167 →	+0.501	+0.024	<.001	<.001	3	5
PDAC	PHF20L1_S433 →	+0.455	+0.016	.001	<.001	3	5
PDAC	RBMX_S352 →	+0.303	+0.013	<.001	.005	3	5
LSCC	RNF20 →	+0.240	+0.031	<.001	<.001	3	5
LSCC	S100A9_T113 →	-1.007	-0.031	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009451 vs SND1_S645 — LSCC

Explore this scatter interactively →