RNA modification

Across TCGA patient cohorts, RNA activity of the RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL12, CDH23, and SIGLEC9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA modification activity versus CXCL12 in OV (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CXCL12 →	-1.568	-0.195	<.001	<.001	3	3
COAD	CDH23 →	-0.126	-0.147	.006	.007	3	3
OV	SIGLEC9 →	-0.693	-0.207	.001	<.001	3	3
OV	EIF5A2 →	-0.853	-0.134	<.001	.008	3	3
COAD	PTAFR →	-0.539	-0.155	.002	<.001	3	3
COAD	RASGRP4 →	-0.567	-0.259	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009451 vs CXCL12 — OV

Explore this scatter interactively →