RNA modification

Across TCGA cell cohorts, RNA activity of the RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGK, ADAR, and SMG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POGK grouped by RNA modification-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POGK →	-0.596	-0.180	<.001	.003	3	5
SKIN	ADAR →	-0.684	-0.206	.001	.008	3	4
CNS	SMG5 →	-0.366	-0.134	<.001	.002	3	4
KIDNEY	PRDM2 →	+0.845	+0.156	.003	.005	3	4
LUNG_NSCLC_LUAD	FLAD1 →	-0.437	-0.093	.001	.003	2	5
OESOPHAGUS	DKK3 →	+3.598	+0.233	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POGK by RNA modification activity — CNS

Explore this box plot interactively →