RNA modification

Across TCGA cell cohorts, RNA activity of the RNA modification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACO1, CEP57L1, and CSKMT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA modification activity versus ACO1 in PANCREAS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACO1 →	-1.037	-0.141	.001	<.001	3	6
URINARY_TRACT	CEP57L1 →	-0.797	-0.292	.002	.001	3	6
KIDNEY	CSKMT →	+0.887	+0.270	.001	<.001	3	5
STOMACH	INPP1 →	-1.988	-0.190	<.001	<.001	3	5
BONE	CHMP2A →	-0.819	-0.218	<.001	.002	3	5
SKIN	ATP6V1F →	-0.951	-0.252	.006	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009451 vs ACO1 — PANCREAS

Explore this scatter interactively →