Gamma-aminobutyric acid metabolic process

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABAT, TPM2, and LAMC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid metabolic process activity versus ABAT in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABAT →	+1.466	+0.186	<.001	<.001	3	6
GBM	TPM2 →	-0.886	-0.260	<.001	<.001	3	6
GBM	LAMC1 →	-0.458	-0.216	.001	.001	3	5
HNSC	P3H1 →	-0.757	-0.185	.002	.002	3	5
GBM	COL6A2 →	-1.580	-0.314	<.001	<.001	3	5
BRCA	LMNA →	-0.499	-0.104	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009448 vs ABAT — BRCA

Explore this scatter interactively →