Gamma-aminobutyric acid metabolic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAU2, CENPN, and ACP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAU2 grouped by Gamma-aminobutyric acid metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAU2 →	+0.653	+0.558	<.001	.004	3	5
LIVER	CENPN →	-1.113	-1.233	.002	.001	3	5
BLOOD_Lymphoma	ACP6 →	-2.842	-1.683	.004	.006	3	4
LUNG_NSCLC_LUAD	MPHOSPH6 →	-0.526	-0.762	.001	.005	3	4
BREAST	MDH1 →	-0.507	-0.800	.005	.002	3	4
LIVER	MRPS36 →	-0.769	-1.168	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAU2 by Gamma-aminobutyric acid metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →