Gamma-aminobutyric acid metabolic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LANCL2, KCNJ14, and AK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LANCL2 grouped by Gamma-aminobutyric acid metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LANCL2 →	-0.142	-0.746	.004	.007	3	4
PANCREAS	KCNJ14 →	+0.140	+1.536	.004	.002	3	4
LUNG_NSCLC_LUAD	AK2 →	+0.093	+1.313	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DCAF11 →	-0.186	-1.791	<.001	<.001	3	3
BONE	CTNNBIP1 →	+0.525	+1.782	.007	.007	1	5
LARGE_INTESTINE	ZWINT →	-0.311	-0.977	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LANCL2 by Gamma-aminobutyric acid metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →