Putrescine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Putrescine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBA7, RGS10, and TRIM22, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Putrescine biosynthetic process activity versus UBA7 in UCEC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBA7 →	-0.331	-0.059	.004	<.001	3	8
GBM	RGS10 →	-0.594	-0.083	<.001	<.001	3	6
LSCC	TRIM22 →	-0.399	-0.067	<.001	<.001	3	6
BRCA	XPO5 →	+0.492	+0.071	.001	.001	3	6
BRCA	CEBPZ →	+0.397	+0.085	<.001	<.001	3	6
BRCA	DCAF13 →	+0.334	+0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009446 vs UBA7 — UCEC

Explore this scatter interactively →