Putrescine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Putrescine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCD2, CHST10, and PLG, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Putrescine biosynthetic process activity versus SMARCD2 in CCRCC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SMARCD2 →	-0.191	-0.090	.001	<.001	3	2
CCRCC	CHST10 →	-0.482	-0.089	<.001	<.001	3	2
CCRCC	PLG →	+1.802	+0.122	<.001	<.001	3	2
CCRCC	SLC35D2 →	+0.257	+0.090	.009	.004	3	2
CCRCC	ZSWIM3 →	-0.251	-0.086	<.001	<.001	3	2
CCRCC	SPATA9 →	-0.358	-0.124	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009446 vs SMARCD2 — CCRCC

Explore this scatter interactively →