Putrescine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Putrescine biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB4, H2BC13, and COPZ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMGB4 grouped by Putrescine biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HMGB4 →	-0.407	-0.170	.003	.004	3	5
BLOOD_Myeloma	H2BC13 →	-0.255	-0.131	.007	.002	3	5
UPPER_AERODIGESTIVE_TRACT	COPZ1 →	-0.359	-0.248	.004	.001	3	5
LUNG_NSCLC_LUSC	BCLAF1 →	+0.355	+0.252	<.001	.002	3	5
BLOOD_Myeloma	RBBP8 →	+0.334	+0.138	<.001	.001	3	4
KIDNEY	BMT2 →	+0.212	+0.217	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMGB4 by Putrescine biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →