Methylglyoxal metabolic process

Across TCGA patient cohorts, RNA activity of the Methylglyoxal metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HAGH, ECI1, and MYEF2_S17, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Methylglyoxal metabolic process activity versus HAGH in OV (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HAGH →	+0.365	+0.065	.001	<.001	3	9
OV	ECI1 →	+0.594	+0.047	.004	.002	3	6
LSCC	MYEF2_S17 →	+0.776	+0.053	.004	.002	3	6
LUAD	HMOX2 →	+0.433	+0.061	<.001	<.001	3	6
LSCC	JUNB →	-0.443	-0.074	<.001	<.001	3	6
BRCA	PDPK1 →	+0.251	+0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009438 vs HAGH — OV

Explore this scatter interactively →