Response to water

Across TCGA cell cohorts, RNA activity of the Response to water pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI16, GPR3, and SH3KBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFI16 grouped by Response to water-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IFI16 →	-3.862	-1.273	<.001	<.001	3	5
LUNG_SCLC	GPR3 →	-1.443	-1.320	.003	.006	3	4
LUNG_SCLC	SH3KBP1 →	-2.431	-0.922	<.001	.007	3	4
OESOPHAGUS	KRT14 →	-5.221	-1.152	<.001	<.001	3	4
LARGE_INTESTINE	ENO2 →	-1.725	-1.305	.002	<.001	3	4
SKIN	MAML2 →	+0.929	+0.738	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFI16 by Response to water activity — BREAST

Explore this box plot interactively →