Response to water

Across TCGA cell cohorts, RNA activity of the Response to water pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERINC2, SYK, and GNB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to water activity versus SERINC2 in LARGE_INTESTINE (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SERINC2 →	+1.839	+0.221	<.001	<.001	3	6
BLOOD_Leukemia	SYK →	+2.389	+0.834	.001	.002	3	6
BLOOD_Leukemia	GNB3 →	-1.018	-0.834	<.001	<.001	3	5
LUNG_NSCLC_LUAD	DFFA →	-0.778	-0.241	.008	.003	3	5
LARGE_INTESTINE	GJB3 →	+1.834	+0.256	<.001	<.001	3	5
BLOOD_Leukemia	CTSZ →	+3.077	+1.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009415 vs SERINC2 — LARGE_INTESTINE

Explore this scatter interactively →