Response to water deprivation

Across TCGA patient cohorts, RNA activity of the Response to water deprivation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, TMCC1_S134, and DDAH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to water deprivation activity versus RPRD2 in HNSC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPRD2 →	-0.217	-0.166	<.001	.005	3	6
PDAC	TMCC1_S134 →	-0.491	-0.079	<.001	<.001	3	5
BRCA	DDAH1 →	-0.756	-0.065	<.001	<.001	3	5
LUAD	MYEF2 →	-0.528	-0.071	<.001	<.001	3	5
HNSC	ARFGEF3 →	-0.397	-0.194	.001	.005	3	5
LUAD	ARHGAP21_S616 →	-0.519	-0.066	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009414 vs RPRD2 — HNSC

Explore this scatter interactively →