Response to water deprivation

Across TCGA cell cohorts, RNA activity of the Response to water deprivation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE6, CSTF2, and CHRDL1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to water deprivation activity versus CPNE6 in LUNG_SCLC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CPNE6 →	+1.299	+1.714	<.001	.004	3	1
LUNG_SCLC	CSTF2 →	+0.875	+1.737	.005	.004	3	1
LUNG_SCLC	CHRDL1 →	+4.630	+1.761	.005	.002	3	1
LUNG_SCLC	UTP18 →	+0.473	+1.605	.009	<.001	3	1
LUNG_SCLC	ROMO1 →	+1.031	+1.605	.006	<.001	3	1
LUNG_SCLC	SRD5A3 →	+1.071	+1.605	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009414 vs CPNE6 — LUNG_SCLC

Explore this scatter interactively →