Response to cold

Across TCGA patient cohorts, RNA activity of the Response to cold pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPM, SKA1, and KIF14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cold activity versus ASPM in PDAC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ASPM →	-0.753	-0.152	<.001	<.001	3	7
LUAD	SKA1 →	-0.803	-0.177	.001	<.001	3	6
PDAC	KIF14 →	-0.713	-0.136	<.001	<.001	3	6
LUAD	KIF11 →	-0.600	-0.136	.003	.004	3	6
LUAD	HASPIN →	-0.496	-0.128	<.001	<.001	3	6
LUAD	TPX2 →	-0.974	-0.147	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009409 vs ASPM — PDAC

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