Response to heat

Across TCGA patient cohorts, RNA activity of the Response to heat pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, C1QB, and C1QC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to heat activity versus SKAP2 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.552	+0.046	<.001	<.001	3	7
CCRCC	C1QB →	+0.556	+0.023	.001	.002	3	7
OV	C1QC →	+0.616	+0.028	.008	.002	2	8
CCRCC	PLEKHO2 →	+0.184	+0.020	.004	.002	3	7
COAD	ELMO1 →	+0.285	+0.017	<.001	.004	3	6
GBM	HCK →	+0.517	+0.045	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009408 vs SKAP2 — GBM

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