Response to heat

Across TCGA cell cohorts, RNA activity of the Response to heat pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC1, MICA, and NNMT, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to heat activity versus EMC1 in BLOOD_Myeloma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EMC1 →	+1.051	+0.082	.002	<.001	3	14
BREAST	MICA →	+2.109	+0.081	<.001	<.001	3	12
STOMACH	NNMT →	+4.171	+0.097	<.001	<.001	3	11
SOFT_TISSUE	HIVEP2 →	+1.149	+0.072	.003	<.001	3	10
OESOPHAGUS	GFPT2 →	+3.035	+0.155	<.001	<.001	3	10
BLOOD_Leukemia	TMCC2 →	+1.201	+0.043	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009408 vs EMC1 — BLOOD_Myeloma

Explore this scatter interactively →