Toxin metabolic process

Across TCGA patient cohorts, RNA activity of the Toxin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WAS, AOC3, and CD248, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toxin metabolic process activity versus WAS in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WAS →	+0.497	+0.256	<.001	.004	3	5
OV	AOC3 →	+1.399	+0.242	<.001	<.001	3	5
GBM	CD248 →	+1.096	+0.177	<.001	<.001	3	5
OV	ARHGAP9 →	+0.768	+0.256	.002	.004	3	4
OV	LOXL2 →	+0.969	+0.260	.001	<.001	3	4
GBM	HLX →	+0.484	+0.160	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009404 vs WAS — LUAD

Explore this scatter interactively →