Toxin metabolic process

Across TCGA cell cohorts, RNA activity of the Toxin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC23IP, C10orf88, and INPP5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC23IP grouped by Toxin metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SEC23IP →	-1.074	-1.320	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	C10orf88 →	-0.647	-1.124	.007	.002	3	4
LUNG_SCLC	INPP5A →	-1.149	-1.328	.009	.003	3	4
OESOPHAGUS	IQCG →	-1.029	-1.377	.002	.007	3	4
OESOPHAGUS	BECN1 →	-0.573	-1.121	.005	.005	2	5
URINARY_TRACT	FAM234B →	-1.400	-1.810	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC23IP by Toxin metabolic process activity — BONE

Explore this box plot interactively →