Toxin metabolic process

Across TCGA cell cohorts, RNA activity of the Toxin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGCB, TBC1D22A, and LYPLA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toxin metabolic process activity versus SGCB in BLOOD_Leukemia (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SGCB →	-1.921	-1.121	<.001	.003	3	4
LUNG_SCLC	TBC1D22A →	+0.822	+1.221	.001	.003	3	4
LARGE_INTESTINE	LYPLA1 →	+0.874	+1.405	.002	<.001	3	3
LARGE_INTESTINE	AKR7A3 →	+2.082	+1.519	.009	<.001	3	3
URINARY_TRACT	TAF4 →	+0.893	+2.033	.005	.005	2	4
LUNG_SCLC	COIL →	-0.714	-1.668	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009404 vs SGCB — BLOOD_Leukemia

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