Folic acid-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Folic acid-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIOX2, SETX_S2639, and PGAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid-containing compound biosynthetic process activity versus RIOX2 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIOX2 →	+0.472	+0.056	<.001	.001	3	5
OV	SETX_S2639 →	+0.734	+0.044	.002	.009	3	4
LSCC	PGAP4 →	+0.940	+0.102	<.001	<.001	3	4
UCEC	MICAL2 →	-0.382	-0.072	<.001	<.001	3	4
GBM	CBR1 →	+0.358	+0.066	<.001	<.001	3	4
OV	BCAR3_S290 →	-0.392	-0.041	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009396 vs RIOX2 — LSCC

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