Folic acid-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Folic acid-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCI, RNU1-2, and SARS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid-containing compound biosynthetic process activity versus FANCI in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCI →	+0.545	+0.180	.004	.003	3	4
HNSC	RNU1-2 →	+1.144	+0.570	.005	.003	3	3
BRCA	SARS2 →	+0.401	+0.165	.001	<.001	3	3
BRCA	TIMM50 →	+0.358	+0.130	.004	.001	3	3
BRCA	SAE1 →	+0.312	+0.147	.009	<.001	3	3
BRCA	THOP1 →	+0.588	+0.145	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009396 vs FANCI — UCEC

Explore this scatter interactively →