Folic acid-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Folic acid-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTN2, TRERF1, and RNF165, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTN2 grouped by Folic acid-containing compound biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RTN2 →	-1.705	-1.422	.001	<.001	3	4
BONE	TRERF1 →	+1.094	+1.795	<.001	<.001	3	4
BONE	RNF165 →	+1.433	+1.642	.002	<.001	3	4
OVARY	ABCC2 →	-1.664	-1.481	.007	<.001	3	4
LARGE_INTESTINE	RPL9 →	+0.460	+0.721	.008	.006	3	4
PANCREAS	S100A2 →	-3.491	-1.333	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTN2 by Folic acid-containing compound biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →