Oligosaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC42BPA, EPS8L1, and TCOF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide biosynthetic process activity versus CDC42BPA in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDC42BPA →	+0.245	+0.050	.001	.001	3	6
LSCC	EPS8L1 →	+0.499	+0.034	.008	.009	3	6
LUAD	TCOF1 →	-0.297	-0.058	<.001	<.001	3	5
OV	CDK18_S14 →	+0.572	+0.031	.002	.002	3	5
LSCC	CDK18_S89 →	+0.848	+0.059	<.001	<.001	3	5
LSCC	LRRFIP1 →	+0.314	+0.056	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009312 vs CDC42BPA — LSCC

Explore this scatter interactively →