Amine catabolic process

Across TCGA cell cohorts, RNA activity of the Amine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL1, ILK, and TRIM68, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRHL1 grouped by Amine catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GRHL1 →	+2.675	+1.592	.002	.005	3	4
URINARY_TRACT	ILK →	-1.261	-1.874	<.001	<.001	3	4
URINARY_TRACT	TRIM68 →	-1.082	-2.064	<.001	<.001	3	4
URINARY_TRACT	S100A14 →	+6.720	+1.794	.004	<.001	3	4
URINARY_TRACT	NOL12 →	-1.332	-2.030	.004	<.001	3	4
LUNG_NSCLC_LUSC	TAGLN →	-2.540	-0.961	.009	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRHL1 by Amine catabolic process activity — URINARY_TRACT

Explore this box plot interactively →