Amine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Amine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSL2, ANP32E, and TMEM102_S218, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine biosynthetic process activity versus MSL2 in HNSC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MSL2 →	-0.466	-0.092	.004	.005	3	5
LSCC	ANP32E →	-0.315	-0.032	.001	.003	3	5
LUAD	TMEM102_S218 →	+0.711	+0.097	<.001	<.001	3	4
UCEC	CAMSAP2_S522 →	-0.569	-0.125	.008	.007	3	4
GBM	HEPH →	+0.336	+0.061	<.001	<.001	3	4
GBM	HEPH_S1145 →	+0.803	+0.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009309 vs MSL2 — HNSC

Explore this scatter interactively →