Amine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Amine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3B, EMC2, and BAIAP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3B grouped by Amine biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	POLR3B →	-0.638	-1.113	.009	.004	3	4
LIVER	EMC2 →	+0.882	+1.607	.001	.003	3	4
BLOOD_Myeloma	BAIAP3 →	+0.907	+1.585	.009	.002	3	4
LUNG_SCLC	TMEM130 →	-2.025	-0.779	.005	.007	3	3
KIDNEY	CTCF →	-0.683	-1.225	.005	<.001	3	3
KIDNEY	KLHDC4 →	-0.684	-1.027	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3B by Amine biosynthetic process activity — KIDNEY

Explore this box plot interactively →