Amine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Amine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE7, PRSS22, and EPHA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine biosynthetic process activity versus CPNE7 in LIVER (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CPNE7 →	+4.006	+0.349	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PRSS22 →	-4.796	-2.092	<.001	.001	3	5
PANCREAS	EPHA1 →	-2.436	-1.071	<.001	.002	3	4
PANCREAS	LSR →	-1.963	-1.104	<.001	.001	3	4
PANCREAS	CYP2J2 →	-1.374	-1.099	.003	.008	3	4
PANCREAS	TMEM177 →	+0.746	+1.151	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009309 vs CPNE7 — LIVER

Explore this scatter interactively →