tRNA transcription

Across TCGA patient cohorts, RNA activity of the tRNA transcription pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF3C2, LRRFIP1, and ADNP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA transcription activity versus GTF3C2 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GTF3C2 →	+0.248	+0.069	<.001	<.001	3	7
LSCC	LRRFIP1 →	-0.311	-0.037	<.001	.002	3	7
HNSC	ADNP →	+0.411	+0.106	<.001	<.001	3	6
LSCC	ILF2 →	+0.203	+0.047	.002	<.001	3	6
LSCC	SMARCD1 →	+0.318	+0.051	<.001	<.001	3	6
LSCC	DHX9 →	+0.257	+0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009304 vs GTF3C2 — HNSC

Explore this scatter interactively →