tRNA transcription

Across TCGA cell cohorts, RNA activity of the tRNA transcription pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3D, OR12D2, and SDCCAG8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3D grouped by tRNA transcription-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POLR3D →	-0.322	-0.282	<.001	<.001	3	4
BLOOD_Lymphoma	OR12D2 →	+0.294	+0.226	<.001	.006	3	4
SKIN	SDCCAG8 →	-0.227	-0.216	.006	.009	3	4
SOFT_TISSUE	MYO3A →	-0.190	-0.331	.002	.009	3	4
CNS	BBC3 →	-0.253	-0.275	<.001	<.001	3	4
KIDNEY	CACNG8 →	+0.164	+0.185	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3D by tRNA transcription activity — SKIN

Explore this box plot interactively →