rRNA transcription

Across TCGA patient cohorts, RNA activity of the rRNA transcription pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC2, ILF2, and ZFR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA transcription activity versus HDAC2 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HDAC2 →	+0.288	+0.042	<.001	<.001	3	7
LSCC	ILF2 →	+0.194	+0.037	<.001	<.001	3	7
HNSC	ZFR →	+0.291	+0.080	<.001	.002	3	7
HNSC	HNRNPU →	+0.224	+0.067	.001	.002	3	7
LSCC	ACTL6A →	+0.251	+0.037	<.001	<.001	3	7
LSCC	NONO →	+0.156	+0.041	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009303 vs HDAC2 — LSCC

Explore this scatter interactively →